منابع مشابه
Combinatorial Tau pseudophosphorylation: markedly different regulatory effects on microtubule assembly and dynamic instability than the sum of the individual parts.
Tau is a multiply phosphorylated protein that is essential for the development and maintenance of the nervous system. Errors in Tau action are associated with Alzheimer disease and related dementias. A huge literature has led to the widely held notion that aberrant Tau hyperphosphorylation is central to these disorders. Unfortunately, our mechanistic understanding of the functional effects of c...
متن کاملStructural impact of proline-directed pseudophosphorylation at AT8, AT100, and PHF1 epitopes on 441-residue tau.
The intrinsically disordered protein tau becomes excessively phosphorylated and aggregates into neurofibrillary tangles in Alzheimer's disease. To obtain insight into the structural consequences of phosphorylation, we characterized a mutant protein of tau in which epitopes recognized by Alzheimer diagnostic antibodies were mimicked by mutation to glutamic acid [AT8 (S199E, S202E, T205E), AT100 ...
متن کاملCombinatorial Interpretations of Ramanujan’s Tau Function
We use a q-series identity by Ramanujan to give a combinatorial interpretation of Ramanujan’s tau function which involves t-cores and a new class of partitions which we call (m, k)-capsids. The same method can be applied in conjunction with other related identities yielding alternative combinatorial interpretations of the tau function.
متن کاملPseudophosphorylation of tau at S422 enhances SDS-stable dimer formation and impairs both anterograde and retrograde fast axonal transport
In Alzheimer's disease (AD), tau undergoes numerous modifications, including increased phosphorylation at serine-422 (pS422). In the human brain, pS422 tau protein is found in prodromal AD, correlates well with cognitive decline and neuropil thread pathology, and appears associated with increased oligomer formation and exposure of the N-terminal phosphatase-activating domain (PAD). However, whe...
متن کاملTau Pseudophosphorylation : Markedly Different Regulatory Effects on Microtubule Assembly and Dynamic Instability than the Sum of the Individual Parts
Erkan Kiris 1,2,4 , Donovan Ventimiglia 1,5 , Mehmet E. Sargin 2,3 , Michelle R. Gaylord 1,7 , Alphan Altinok 2,3,6 , Kenneth Rose 2,3 , B.S. Manjunath 2,3 , Mary Ann Jordan 1 , Leslie Wilson 1,2 , and Stuart C. Feinstein 1,2,§ . From the 1 Neuroscience Research Institute and Department of Molecular and Cellular and Developmental Biology, the 2 Center for Bio-Image Informatics and 3 Electrical ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2011
ISSN: 0021-9258
DOI: 10.1074/jbc.m111.219311